Cortisol Metabolism in Human Obesity: Impaired Cortisone→Cortisol Conversion in Subjects with Central Adiposity1
نویسندگان
چکیده
منابع مشابه
Cortisol metabolism in human obesity: impaired cortisone-->cortisol conversion in subjects with central adiposity.
For a given body mass index (BMI), mortality is higher in patients with central compared to generalized obesity. Glucocorticoids play an important role in determining body fat distribution, but circulating cortisol concentrations are reported to be normal in obese patients. Our recent studies show enhanced conversion of inactive cortisone (E) to active cortisol (F) through the expression of 11b...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1999
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.84.3.5538